Round eight of the Premier League season will kick off with a bang, with Manchester United visiting fierce rivals Liverpool at Anfield.
The Reds have fallen seven points behind their north-west neighbours already but boast an excellent record against fellow title contenders they will be hoping to maintain.
Manchester City, Chelsea, Tottenham and Arsenal are all in action later on Saturday before a pair of Sunday games and Leicester City's clash with West Brom on Monday night.
Goal has your complete guide to the latest set of fixtures, including the updated table.
Liverpool host Manchester United at 12:30 on Saturday, with the Red Devils having the chance to put 10 points between themselves and Jurgen Klopp's men at this early stage in the campaign.
The rest of England's Champions League clubs are also in action on Saturday due to the upcoming week of European fixtures.
Manchester City take on Stoke City at 15:00, with Chelsea visiting struggling Crystal Palace and Tottenham back at Wembley to face Bournemouth.
Swansea City face Huddersfield Town and Burnley meet West Ham before, at 17:30, Watford look to continue their strong start to the new campaign at home against Arsenal.
On Sunday, Brighton take on Everton in a game which has been moved to be broadcast on Indian television but will not be shown in the UK.
Southampton's match against Newcastle United at St Mary's will be live on Sky Sports later in the day, as will Leicester City's Monday-night matchup against West Brom.
In the UK, Premier League games will be available to watch live on Sky Sports and BT Sport, with the BBC broadcasting highlights on Match of the Day. Viewers will also be able to stream games live online using Sky Go and the BT Sport app.
In the U.S., up to 250 Premier League games will be available to watch live on television on NBC's various channels, including NBC, NBCSN and CNBC. These games can be streamed on NBC Sports Live.
The network also announced in June that a further 130 games would be exclusively available with the 'Premier League Pass' on NBC Sports Gold. The 'Premier League Pass' service will cost $50.
Harry Kane had his scoring boots on once again, finding the target twice as Tottenham thrashed Huddersfield Town 4-0 in the Saturday lunchtime game. Ben Davies and Moussa Sissoko also netted for Spurs.
Five 15:00 fixtures then followed, with Manchester United also winning 4-0 thanks to two Marouane Fellaini goals against Crystal Palace. Juan Mata and Romelu Lukaku were also on the scoresheet.
High-flying Watford held West Brom to a 2-2 draw away from home thanks to Richarlison's 95th-minute equaliser but there was less drama at Bournemouth, who drew 0-0 with Leicester City.
West Ham recorded a much-needed 1-0 win at home against Swansea City and Stoke City were 2-1 victors over Southampton.
In the Saturday evening kick-off, Kevin De Bruyne's precise strike from 20 yards ensured Manchester City's fine performance at Chelsea was rewarded with three points.
On Sunday, Arsenal climbed into the top five with a 2-0 home victory against Brighton.
Everton's early-season woes continued as they were downed by Burnley in a north-west match-up before the action closed with Rafa Benitez holding his former employers to a point, as Newcastle United drew 1-1 with Liverpool.