Diego Alonso makes eight changes from their 1-1 draw with Celta Vigo at the weekend. The only survivors are the two centre-backs, Loic Bade and Nemanja Gudelj, and the midfield Djibril Sow. The captain Jesus Navas and vice-captain Ivan Rakitic are among those left out.
These are the XIs in full.
Arsenal (possible 4-1-2-3) Raya; White, Saliba, Gabriel, Tomiyasu; Jorginho; Havertz, Rice; Saka, Trossard, Martinelli.
Substitutes: Ramsdale, Hein, Cedric, Kiwior, Zinchenko, Vieira, Nelson, Elneny, Cozier-Duberry, Sagoe Jr.
Sevilla (possible 4-3-3) Dmitrovic; Juanlu, Bade, Gudelj, Kike Salas; Sow, Fernando, Jordan; Lamela, En-Nesyri, Pedrosa.
Substitutes: Alberto Flores, Gattoni, Ocampos, Suso, Rafa Mir, Rakitic, Lukebakio, Mariano Diaz, Nianzou, Jesus Navas,
Oliver Torres, Soumare.
Referee Istvan Kovacs (Romania)