Marcus Rashford returns to the Manchester Utd starting XI, replacing Antony, in their only change from the 1-0 win at Fulham at the weekend.
Raphael Varane remains among the subs as Erik ten Hag opts for Harry Maguire and Jonny Evans at centre-back.
Man United: Onana; Wan-Bissaka, Maguire, Evans, Dalot; McTominay, Eriksen; Garnacho, Fernandes, Rashford; Hojlund.
Subs: Bayindir, Heaton, Lindelof, Reguilon, Varane, Amrabat, Forson, Hannibal, Mount, Pellistri, Antony, Martial.
Copenhagen have made three changes following their win over Randers at the weekend.
Oscar Hojlund, younger brother of Manchester United striker Rasmus Hojlund, drops to the bench, with Diogo Goncalves taking his place. The other two changes are made in attack, where Viktor Claesson and Mohamed Elyounoussi come in.
Copenhagen: Grabara; Ankersen, Vavro, Diks, Jelert; Lerager, Falk, Goncalves; Elyounoussi, Claesson, Achouri.
Subs: Sander, Dithmer, Sorensen, Tanlongo, Larsson, Babacar, Oskarsson, Boilesen, Lund, O. Hojlund, Bardghji, Froholdt.